Endocrine Abstracts

Recent reports have raised concerns that dopamine agonist drugs, particularly cabergoline and pergolide, may be associated with cardiac valvulopathy. Dopamine agonists exert their prolactin-suppressive effect via lactotroph D2S receptors, while cardiac fibrosis appears to be mediated via 5HT2B receptors. We have assessed the receptor binding and functional effects of a range of dopamine agonists to determine their relative potencies at these two receptors...